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The contribution of Computational Biology in Medicine and consequently in Biofabrication

Modern systems are complex, including heterogeneous subsystems and components, such as software, devices, equipment, which are influenced by the human factor. This would be no different when we speak of biological systems, which have to rigorously orchestrate all the biomolecular and biostructural components to ensure life.


Therefore, the reliability analysis of a complex system is an important problem for science and technology.


There are different methods in reliability engineering for analysis and quantification of each biological component, but a trend of these analyzes is the creation of new methods, which evaluate the system as a whole.


According to this trend, new algorithms and methods of artificial intelligence are modeled to remedy these gaps, and in the future, be used for emerging areas such as biofabrication of a tissue and organ.

In the videos and figure below, I present some in silico platform ideas, being developed by innovative companies, such as Insilico Medicine and Biotime.


Bio3Data is a startup that develops solutions for the biological area in order to minimize time, costs and the use of animals in research.


We developed in silico approaches for the analysis of biological data using artificial intelligence and computational simulation.


With this innovative method, we will provide integrative solutions for the development of BioModel Predictive of tissues in Bioprinting of tissues.






In silico Medicine

Embryonic AI: Analysis of Embryonic State using Deep Neural Networks (Property of Biotime, Inc)

Biotime leads the next revolution in regenerative medicine and consequently is a stimulus to the advancement of organ biofabrication.


The company's strategy is to be a leader in the development of pluripotent stem cell technologies and to apply these technologies in the treatment of degenerative diseases that afflict large numbers of people around the world.


The fundamental purpose of such companies is to be the beginning of the next revolution in medicine - regenerative medicine and organ biofabrication.


Regenerative medicine, integrated with biofabrication and computational biology, uses advances in cell biology, biomaterials, compromised cells, and engineering tools to deliver functional cells, tissues, and organs to patients with chronic or degenerative diseases who have suffered trauma.


This revolution in medical science shifts the focus from treating the symptoms of chronic, degenerative diseases and tragic damage, to delivering real cures with innovative technologies.

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