The term Biofabrication has been widely used by a variety of areas of knowledge and revised in recent scientific articles (available in publications), but the most current concept accepted by scientific society is " the automated generation of biologically functional products with structural organization from living cells, bioactive molecules, biomaterials, cell aggregates such as micro-tissues, or hybrid cell-material constructs, through Bioprinting or Bioassembly and subsequent tissue maturation processes."
Biofabrication of tissues and organs is an emerging and demanding technology in terms of multidisciplinarity. This area is part of tissue engineering, composed of several technologies, such as 3D bioprinting. The purpose of these fields is to build and rebuild damaged tissues and organs in order to save or improve patients' lives.
The main idea of this scheme is the use of computational simulations to develop more accurate and reliable biological models for bioprinting. These models are useful for a better understanding of biological phenomena (flow and diffusion of nutrients, adhesion, cell growth and differentiation, among others) which exist in the morphogenesis and regeneration of a new tissue or organ.
While this technology is advancing, many processes are presumed to exist and do not yet exist in research and commercially. What we find today are some tools and processes being developed for the constant improvement of existing technology, mostly in research only.
Other work in progress will be shown on the ongoing projects page.
There is certainly a great need for the creation and incorporation of software and parameters more appropriate for this area, being indispensable the integration of several areas, mainly information technology (IT).
It is obvious that without a virtual model it is not possible to proceed with the steps of biofabrication. In addition, the combination with mathematical modeling, biological algorithms and computer simulation can identify potential problems, find a better solution and optimize digital models, and thus facilitate all phases of biofabrication of a functional biological tissue.
The videos presented were developed during my postdoctoral at the Center Information Technology Renato Archer along with fellow researchers.
All information is on our YouTube channel - Biofabrication